Chris Halbrook

If you want to know more about chemoresistance to gemcitabine in pancreatic cancer, look no further. You will also find some great figures to use for your future talk needs here: https://journals.physiology.org/doi/full/10.1152/ajpcell.00331.2022?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

We show that (1) metabolic subtypes exist within pancreatic tumors, (2) these populations exchange nutrients to support each other, (3) among these, asparagine can support mitochondrial metabolism, (4) degradation of asparagine enhances mitochondrial targeting, and (5) the differences in metabolism between clones are due to a constitutive vs. inducible stress response. Check it all out here: https://www.nature.com/articles/s43018-022-00463-1

This funding will allow us to build out our investigation of the primary vs. metastatic niche in pancreatic cancer.