We are grateful for this generous funding to continue this work.
News
Chris received a Young Investigator in Pancreatology Award from the American Pancreatic Association
We are very grateful for this support to continue our work in pancreatic cancer cell heterogeneity.
Alica’s gemcitabine resistance review is out
If you want to know more about chemoresistance to gemcitabine in pancreatic cancer, look no further. You will also find some great figures to use for your future talk needs here: https://journals.physiology.org/doi/full/10.1152/ajpcell.00331.2022?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
Our Nature Cancer metabolic heterogeneity paper is (finally!) out
We show that (1) metabolic subtypes exist within pancreatic tumors, (2) these populations exchange nutrients to support each other, (3) among these, asparagine can support mitochondrial metabolism, (4) degradation of asparagine enhances mitochondrial targeting, and (5) the differences in metabolism between clones are due to a constitutive vs. inducible stress response. Check it all out here: https://www.nature.com/articles/s43018-022-00463-1
Alica gave a fantastic short talk at the AACR Special Conference on Pancreatic Cancer
